Genetic Test
The ENAM (Enamelin) gene encodes a protein that plays a crucial role in the mineralization and structural organization of dental enamel, the hard outer layer of the tooth.
Enamelin is essential for the proper formation and integrity of enamel during tooth development.
Mutations in the ENAM gene can lead to enamel hypoplasia, a condition in which the enamel is abnormally thin, soft, or incomplete, making teeth more vulnerable to wear, sensitivity, and decay.
This genetic test targets two known ENAM mutations associated with enamel hypoplasia.
Disease Description
Enamel is the hardest substance in a dog’s body and forms a protective outer layer over the surface of the teeth.
It is produced by specialized cells called ameloblasts during tooth development.
Enamel hypoplasia is a condition caused by genetic defects in ameloblast function, leading to insufficient or defective enamel formation.
Dogs affected by this condition may have teeth that are more prone to gum disease (periodontal disease), tooth sensitivity, and dental caries (cavities)
due to the compromised enamel layer.
