Genetic Test
The BLZF1 (Basic Leucine Zipper Nuclear Factor 1) gene encodes a protein involved in intracellular protein transport, helping regulate the movement and localization of proteins within the cell.
Mutations in BLZF1 have been associated with an increased genetic risk for patellar luxation, a condition in which the kneecap (patella) dislocates from its normal position, leading to joint instability and abnormal gait.
This genetic test targets a specific BLZF1 mutation linked to patellar luxation.
However, it is important to note that patellar luxation is a multifactorial condition—influenced not only by genetics but also by environmental and anatomical factors such as joint conformation, trauma, and body condition.
Disease Description
The patella, or kneecap, is a small bone in a dog’s stifle (knee) joint that plays a key role in movement during walking.
It helps guide the motion of the knee by working in coordination with surrounding muscles and ligaments, allowing for smooth joint function.
Patellar luxation is a condition in which the patella slips out of its normal position—either toward the inside (medial) or outside (lateral) of the leg.
This displacement can cause pain, lameness, and an abnormal gait, often observed as skipping, limping, or reluctance to bear weight on the affected limb.
