Genetic Test
The SUV39H2 (Histone-lysine N-methyltransferase SUV39H2) gene encodes an enzyme that transfers methyl groups to histone proteins.
Histones are proteins that package and organize DNA strands, playing a crucial role in regulating gene transcription.
Methylation of histones by this enzyme influences various cellular processes, including cell cycle regulation and transcriptional repression.
This genetic test targets a specific mutation in the SUV39H2 gene associated with nasal hyperkeratosis, a condition characterized by excessive thickening of the nasal skin.
Disease Description
Nasal hyperkeratosis is a hereditary skin disorder characterized by the accumulation of thick, hard, and dry keratin on the nose pad.
Affected dogs typically develop crusting and fissures on the surface of the nose, which can trap secretions such as nasal discharge and other bodily fluids within the cracks.
This condition is generally non-contagious and, apart from the nasal symptoms, most affected dogs remain otherwise healthy.
