Genetic Test
The ABCB1 (ATP Binding Cassette Subfamily B Member 1) gene encodes a membrane transport protein that facilitates the movement of various chemical substances into and out of cells.
This protein, also known as P-glycoprotein, plays a crucial role in protecting sensitive tissues—such as the brain—by actively transporting potentially harmful drugs and toxins out of cells, particularly in organs like the liver, kidney, and the blood-brain barrier.
Disease Description
Multidrug sensitivity refers to an abnormal, often severe reaction to certain medications or toxins due to a genetic mutation.
Dogs with this condition are especially susceptible to
ivermectin-based drugs
, which can cause life-threatening neurological effects when administered, even at standard doses.
However, dogs carrying this mutation can live perfectly normal, healthy lives as long as they are not exposed to the triggering medications.
Genetic testing is essential for identifying at-risk individuals and ensuring safe drug selection in clinical practice.
