Genetic Test
The PKD1 (Polycystin-1) gene encodes a protein that plays a critical role in the development and maintenance of renal tubules within the kidneys.
This protein is involved in cellular signaling pathways that regulate kidney structure, cell proliferation, and tubular integrity.
Mutations in the PKD1 gene can disrupt normal kidney development, leading to the formation of fluid-filled cysts—a condition known as polycystic kidney disease (PKD).
This genetic test targets a specific PKD1 mutation associated with polycystic kidney disease.
Disease Description
Polycystic kidney disease (PKD) is characterized by the presence of multiple fluid-filled cysts within the kidneys.
These cysts may be present at birth but often enlarge progressively with age. The rate of cyst growth can vary widely between individuals.
As the cysts expand, they can compress and replace normal kidney tissue, ultimately leading to chronic kidney failure.
While PKD can occur in dogs, it is
more commonly observed in cats
, particularly in certain breeds with known genetic predispositions.
